We knead how many units. How Mezim works - how this medicine differs from its analogues. Side effects and contraindications

What is better “Mezim” or “Pancreatin” for pancreatitis? This is a common question. Let's find out in this article.

About diseases of the pancreas

Pancreatic diseases are becoming more common. The reason for this is the reduced resistance to stress of modern people, the poor environment, and bad habits, such as rich fatty and sweet menus, smoking, and alcohol.

All this leads to disturbances in the gastrointestinal tract, and they, in turn, cause a reduced level of enzymes that break down food into less complex components for good absorption by the body. And this directly affects the pancreas, diseases of which are characterized by the irreversibility of processes in its tissues.

Most Popular

“Mezim” and “Pancreatin” (we’ll find out which is better below) remain the most popular medications for people suffering from pancreatic diseases. There is often debate on various forums about which of these medications is the best. Let's look at how the first medicine differs from the second.

Pharmacological characteristics of "Pancreatin"

This drug is based on pork pancreas juice. Other components are enzymes - protease, amylase, lipase. The special coating that covers the tablets is designed to protect the enzymes it contains from the effects of stomach acid. At the same time, it is this acid that activates their action.

"Pancreatin" is recommended for use by those people who suffer from chronic pancreatitis, enzyme deficiency, gastritis, flatulence and any disturbances in the digestive process.

People often ask which is better - Mezim, Festal or Pancreatin.

At the same time, the drug is contraindicated in those patients in whom its animal component causes intolerance. Plus, it should not be consumed by pregnant women or those suffering from acute pancreatitis.

As a rule, no problems arise when taking Pancreatitis, but in some cases reactions in the form of nausea or vomiting are possible. As for pregnancy, the effect of the contents of the drug on the health of the fetus and the maternal body has not been studied, since appropriate tests have not been conducted.

What is better “Mezim” or “Pancreatin”? There are a lot of reviews on this matter.

Flaw

The disadvantage of "Pancreatin" is that its instructions do not provide a clear number of units of all components, and because of this, its exact dosage is difficult. The price for it is quite low - from 20 to 75 rubles, which, of course, increases its popularity. In addition, it is available in almost all pharmacies; they import it in large quantities. This medicine should be taken with or after meals with water.

Since the concentration of pancreatin in this drug compared to other analogues is low, it only treats mild degrees of gastrointestinal disorders. The doctor can prescribe from 1 to five tablets per dose - this depends on the patient’s body weight.

So, the advantages of “Pancreatin” include its availability, low cost, and also the absence of harmful effects on the gallbladder. In addition, it is practically not counterfeited. But the disadvantages in the form of unclearly prescribed doses of active substances, intolerance to some of them and rather weak protection against stomach acid sometimes really bother some of the patients.

So, which is better - Mezim or Pancreatin?

Pharmacological characteristics of "Mezim"

Its main component - pancreatin - is similar to that contained in the medicine described above. The dosage of all components is clearly indicated. This is 4200 units of amylase, 250 of protease, 3500 of lipase. There are other substances in the composition of the product that are auxiliary. A version of the drug called "Mezim 20000" contains twice as much pancreatin in its composition.

A sufficient amount of the main active ingredient makes this drug a more effective remedy than Pancreatin in the fight against the symptoms and causes of housing and communal diseases. But at the same time, you should be careful with its dosage.

The drug itself is produced in Germany, so its price is much higher than that of Pancreatin, which means the risk of running into a fake is also higher.

The main reason for its use is the prevention of pancreatic dystrophy, as well as the treatment of chronic inflammation. It is also prescribed for chronic gastritis, and it also relieves well the symptoms that accompany overeating.

What is better - “Panzinorm”, “Mezim”, “Festal”, “Creon”, “Pancreatin”? All these remedies are very similar in their action.

"Festal" is a combined enzyme preparation that helps improve digestion processes. The main pharmaceutical property of this drug is to ensure the breakdown of proteins, fats and carbohydrates in the small intestine.

Here is only an incomplete list of Festal analogues, including drugs that are the most popular and frequently prescribed today:

• "Pancreatin".
• "Panzinorm."
• "Penzital".
• "Creon."
• "Uni-Festal".
• "Pancitrate."
• "Hermital".
• "Enzistal".
• "Mezim."
• "Biozyme".

A well-made advertisement for Mezim leads to people taking it even for those cases where it is not indicated at all - in situations of food poisoning, for nausea. Or they take it “just in case,” actually just like that, believing that it will improve digestion. Under no circumstances should you do this.

How to prescribe

As a rule, Mezim is prescribed in the amount of one or two tablets before meals. But again, the dosage depends on the patient’s weight, and it must be determined by the doctor. The same as the dosage for children. As a rule, they are not prescribed for children under three years of age. The drug is also not recommended for pregnant women. You need to take these tablets with plenty of clean water.

Which is better: “Mezim” or “Pancreatin” or “Creon”, it can be very difficult to decide.

Side effects of this medication may include diarrhea, nausea, vomiting, and increased urea levels.

This drug is effective in the treatment of both mild and serious forms of gastrointestinal disorders, since the content of the active substance in it is increased.

Pros

So, the advantages of Mezim include clear and detailed information about the doses of all substances in one tablet, increased effectiveness of the effect on the patient’s body, as well as proven German quality. And its disadvantages are its high cost, a higher number of “side effects” in comparison with “Pancreatin”, plus the likelihood of purchasing a counterfeit instead of the original medicine.

And according to people’s reviews, which is better - “Mezim” or “Pancreatin”. More on this below.

What the reviews say

We studied the reviews that people left on websites where these medications are sold and on forums. Debates about the benefits of one of these two drugs are very common, but the main conclusions are as follows:

• Some users highlighted the cost of "Pancreatin" as an undeniable advantage of this drug.
• Some wrote that they encountered side effects when using this medicine - it made them feel sick.
• On medical forums, experts spoke of Pancreatin as a drug with very weak effects;
• "Mezim", judging by the reviews, is more effective - this was written by users who tried both drugs.
• The high price of Mezim often makes it inaccessible to people with low incomes who suffer from chronic diseases for which this drug is an indication.
• On medical forums, doctors noted its higher effectiveness compared to Pancreatin.

Which is better: “Micrazim”, “Mezim”, “Pancreatin”, it’s up to you to decide.

Conclusions

Analysis of the pros and cons of both drugs does not give a clear answer to the question - which of them is better? Be that as it may, their appointment should be prescribed by a doctor, namely a gastroenterologist. He should answer your questions and justify the choice of this medicine. However, we can say that the dosage of the active component of Mezima and Pancreatin is very individual and depends on many conditions - the nature of the disease, its severity, the presence of contraindications, the patient’s body weight, etc. Under no circumstances should you self-prescribe these medications. At best, there is a chance to experience their “side effects”. Well, in the worst case, you end up in the hospital.

Which is better, “Mezim” or “Pancreatin”, it is still better to check with your doctor.

With the question “Which is better: pancreatin or mezim?” any pharmacy visitor faces. We already know that enzyme preparations can be used without a doctor’s prescription. But I would like to clarify the advertising information for myself. Let's assume that the basis of both drugs is pancreatin.

When are pancreatin and mezim indicated?

Both drugs are used for insufficient enzyme activity of the pancreas to normalize food absorption.

Dosage of pancreatin and mezim

We are accustomed to the dose of one tablet being indicated on the package. For Pancreatin, the dose is indicated in mg (tablets of 250 and 300 mg), for Mezim - in units of activity. For comparison, they must be in the same measures. Mezim contains 3.5 thousand units of lipase, 4.2 thousand units of amylase and 250 units of protease.

It turns out that the dosage of pancreatin is sufficient, we just have to believe!

The daily dose of all enzyme food preparations is calculated based on the lipase content: 50-100 thousand units are enough for children, 150 thousand units for adults. If we do some simple arithmetic, we find out that children, depending on age, need to take from 14 to 28 Mezim tablets per day, adults - 42 tablets.

What about Pancreatin? Generally unknown? Wikipedia assures us that one tablet of Pancreatin is equivalent to 8 thousand units of lipase, so it is recommended to use the drug up to four tablets at once (32 thousand units).

For comparison, we get: one Pancreatin tablet is 2.3 times stronger in its substitutive effect than a Mezim tablet. By repeating the dose 4-5 times we will reach the daily dosage.

But the pharmacy does not have Wikipedia, and not everyone can familiarize itself with it, but the “Instructions for Use” are sealed in each package.

So which is better: pancreatin or mezim?

As a result of our “investigation” the following conclusions suggest themselves:

• a very weak drug, perhaps suitable for treating children (or adults who like to take ten tablets at a time);
• Mezim is more than twice as active;
• both drugs are used only for functional enzyme deficiency and are not indicated for serious diseases of the liver, gall bladder, or pancreas;
• as consumers, we are dissatisfied with the native pharmaceutical industry, which hides from us information about the activity of the enzymes that make up Pancreatin, a domestic drug;
• if symptoms of enzyme deficiency appear, you can start on your own by using Mezim, if it helps, then the disorders are still mild, and this is reassuring;
• and if it doesn’t help, you need to be examined by a gastroenterologist and look for a stronger medicine than both.

You can also see the detailed list

Disruption of the digestion process of food in a child or adult is a common occurrence, accompanied by various unpleasant symptoms, such as bloating, nausea, diarrhea, constipation, etc. Mezim Forte tablets are an affordable drug, the use of which is aimed at replenishing the lack of gastric enzymes and restoring functions of the digestive tract. To quickly improve your health, you need to know how to use the medication correctly and in what dosage.

What is Mezim forte

This medicine belongs to a group of enzyme preparations designed to improve food digestion processes. Doctors recommend using Mezim for diseases associated with pancreatic insufficiency and dysfunction of the gastrointestinal tract. Release form of the drug:

• Mezim forte 10000: pink-coated pellets of a flat, cylindrical shape with beveled edges. They are produced in blister packs of 10 pieces, packaged in 20 or 50 pills;
• Mezim forte 20000: tablets coated with a smooth white or grayish shell with possible internal brown inclusions, have a pronounced odor. Packed in a blister - 10 pieces, available in packages of 10, 20 or 50 pieces.

Benefits and harms of Mezim

The medication is prescribed for digestive disorders, both severe and minor. It is important to remember that regardless of the effectiveness of the medication, course therapy is carried out only with the permission of the doctor. If all rules are followed, the drug has a beneficial effect on the body. By supporting the functioning of the pancreas, Mezim Forte helps to normalize the digestion of carbohydrates, proteins and fats, increase the absorption of valuable substances in the small intestine, and relieve the feeling of heaviness when overeating.

Self-medication, accompanied by an uncontrolled number of tablets, can cause significant harm to patients if Mezim is taken if there are contraindications. Having a powerful effect, in case of overdose the medicine increases the severity of symptoms and leads to poisoning. There are conditions in which drinking pills is strictly prohibited. These include, for example, acute pancreatitis, intolerance to components.

Compound

If a doctor has prescribed Mezim, the composition of the tablet will help you find out what this drug is and what its principle of operation is. The medicine contains active and auxiliary elements. The main active ingredient is pancreatin, a multienzyme component designed to compensate for the deficiency of exocrine function. Additional ingredients include pancreatin enzymes:

• lipase;
• amylase;
• protease;
• trypsin;
• chymotrypsin.

The drug Mezim 10000 differs from Mezim 20000 in that the latter includes twice as many active components that can cope with the symptoms faster and more effectively. Mezim 10000 is relevant for the treatment of diseases associated with the function of the gastrointestinal tract; it is used for intestinal infections, stool disorders, and also as an emergency remedy to help digest fatty foods. Mezim 20000 is indicated for chronic pancreatitis and other diseases of the stomach that have entered the chronic stage.

Pharmacological action

Pancreatin is obtained by extracting pork pancreas. This substance helps digest proteins, fats, and carbohydrates. In this case, the absorption of the digestive enzymes themselves does not occur - they are excreted naturally through the intestines. After taking Mezim forte, the absorption of microelements improves, which allows you to increase important indicators of blood composition. Amylase is effective in the treatment of cystic fibrosis. The enteric coating protects enzymes from the effects of gastric juice, ensuring the lipolytic activity of the drug.

What does it help with?

Mezim Forte is a good remedy that helps the body cope with heavy food during its consumption. The drug compensates for the lack of enzymes, facilitates the absorption of food, and prevents the development of complications due to poor nutrition. The main indications for the use of the drug are:

• chronic pancreatitis;
• inflammation in the gallbladder, liver and stomach;
• cystic fibrosis;
• secretory pancreatic insufficiency;
• intestinal infectious diseases;
• flatulence;
• disruption of the digestion process;
• problems with stool (diarrhea, constipation).

How long does it take for Mezim to work?

The maximum effect of therapy after using the medicine is observed after half an hour. According to patient reviews, Mezim Forte has excellent tolerability, quickly eliminates discomfort, and relieves abdominal pain. Patients using the medication noticed an improvement in their well-being within 10 minutes. After a short time, bloating and heaviness disappear, and the discomfort stops.

Instructions for use Mezim forte

The medicine is dispensed without a prescription, however, with long-term use, the dose is determined by the doctor individually. Before taking Mezim, it is recommended that you carefully read the leaflet. The treatment regimen depends on the type and severity of the disease, the number of symptoms. Standard therapy involves:

1. adults: 1-2 tablets 1-3 times a day;
2. children aged 12-18 no more than 20,000 IU of lipase per 1 kg of body weight;
3. for a child under 12 years old – up to 1500 IU per 1 kg of weight.

The tablets are taken orally before meals or during meals. The medicine is drunk whole, without chewing, accompanied by a large volume of water, so as not to destroy the acid-resistant top layer. The treatment course can last from 1 day to several months. If, when diagnosing digestive pathologies, a specialist prescribed replacement therapy with Mezim, the method of administration involves its constant use in accordance with the doses specified by the doctor.

Instructions for use for children

Mezim is prescribed to a child as a supportive agent for gastrointestinal disorders. A single dose of the medication helps eliminate the consequences of accidental overeating, poisoning or errors in the diet. It is effective for treating children suffering from pancreatitis, diseases of the biliary tract and duodenum. Capsules are prescribed to children according to the following scheme:

1. 1-7 years – ¼ -1 tablet no more than 3 times a day;
2. 7-12 years – 1-2 tablets up to 3 times a day;
3. 12-18 years – up to 20,000 IU of lipase per 1 kg of weight.

The duration of therapy depends on the state of health and ranges from 4 to 30 days. To avoid a decrease in the drug effect, it is better to swallow the capsule whole with a sufficient amount of liquid. Small children can be given the product crushed in water using a plastic syringe. It is not recommended to use enzymes for newborns and babies under 1 year of age.

During pregnancy and breastfeeding

The instructions for use developed for the drug Mezim allow the medication to be taken during pregnancy. However, doctors advise resorting to treatment only in extreme cases, when the benefits to the mother are higher than the possible risks to the gestating fetus. If side effects occur, you should immediately stop using enzymes. While breastfeeding, drinking enzymes is not prohibited.

Drug interactions

When used simultaneously with iron-containing medications, the level of iron absorption into the blood decreases. Indicators of poor absorption of this microelement are: weakness, dizziness, development of anemia. Taking Mezim together with antacids, including magnesium and calcium, is possible when using high doses of the drug, since the effectiveness of the enzyme ingredients is significantly reduced.

Side effects

Mezim is well tolerated by the body and has virtually no negative aspects. To eliminate the consequences, a diet and refusal of medication are prescribed. Side effects are observed with long-term use of the drug or overdose. Among them it is noted:

• nausea;
• aching pain affecting the entire abdominal cavity;
• allergy;
• failure of the intestines;
• increased concentration of uric acid;
• hyperuricemia.

Contraindications

The use of enzymes is not recommended if there is high sensitivity to at least one of the components included in the drug. You should not use Mezim if you are intolerant to enzymes of animal origin. Contraindications to taking the drug are exacerbation of pancreatitis and acute chronic pancreatitis.

Analogs

The pharmaceutical market offers a wide range of enzyme supplements. They are similar in composition, differing only in the amount of amylase and excipients. Medicines in this group are intended to restore digestive processes and maintain the function of the gastrointestinal tract of people leading a sedentary lifestyle, so they should always be in the home medicine cabinet. The main analogues of Mezim include:

• Pancreatin;
• Festal forte;

Video

Attention! The information presented in the article is for informational purposes only. The materials in the article do not encourage self-treatment. Only a qualified doctor can make a diagnosis and give treatment recommendations based on the individual characteristics of a particular patient.

Found an error in the text? Select it, press Ctrl + Enter and we will fix everything!

Instructions for use:

Mezim is an enzyme preparation that promotes the digestion process.

Pharmacological action

Mezim has proteolytic (breaks down proteins into amino acids), amylolytic (promotes the decomposition of starch into madose and oligosaccharides) and lipolytic properties (breaks down fats into fatty acids and glycerol).

The active ingredient of the drug is pancreatin, which is an enzyme from the pancreas of animals, usually pigs.

The analgesic effect of Mezim is due to the properties of trypsin, one of the enzymes that suppresses excessive secretion of the pancreas.

The use of Mezim allows you to compensate for the lack of your own enzymes, thereby improving the digestion of food. A special shell protects pancreatin from the action of gastric juice, allowing it to reach and be released in the small intestine. Maximum enzyme activity can be observed 30-45 minutes after oral administration of Mezim.

Mezim analogues are drugs containing pancreatin and having a similar pharmacological effect.

Analogues of Mezim include Biozim, Gastenorm forte, Creon, Pancreatin, Festal, Ermital.

Indications for use of Mezim

• diseases characterized by insufficiency of the exocrine function of the pancreas (chronic pancreatitis, cystic fibrosis, etc.);
• chronic inflammatory-dystrophic diseases of the gallbladder, liver, intestines, stomach;
• conditions after resection (operation to remove part of the stomach) or irradiation of the digestive system, gall bladder, liver, which are accompanied by impaired digestion of food, diarrhea, flatulence;
• errors in diet, eating unusual or fatty foods to facilitate digestion;
• impaired chewing function, prolonged immobility or sedentary lifestyle;
• preparation for x-ray examinations or ultrasound of the abdominal organs.

Contraindications

Mezim should not be taken in case of acute pancreatitis, exacerbation of chronic pancreatitis, or hypersensitivity.

It is not recommended to take Mezim during pregnancy and breastfeeding, since adequate studies on the safety of this drug have not been conducted. Mezim during pregnancy can be prescribed by a doctor if alternative treatment methods are ineffective.

Instructions for use Mezim

One tablet of Mezim Forte contains pancreatin, in which the minimum enzyme activity of lipase is 3500 IU, protease - 250 IU and amylase - 4200 IU.

One tablet of Mezim forte 10,000 contains pancreatin, in which the activity of lipase, protease and amylase is 10,000 units, 375 units and 7500 units, respectively.

The instructions recommend taking Mezim before meals, entirely, without violating the integrity of the membrane, with plenty of liquid (preferably fruit juices, alkaline water). The usual single dose of the drug is 1-2 tablets; if necessary, additional 1-4 tablets can be taken with meals. The average daily dose of Mezim for adults is 150 thousand units of lipase, with complete deficiency of its own enzymes - 400 thousand units of lipase. Mezim, use must be agreed with a doctor, children under 1.5 years old are prescribed a dose equal to 50 thousand units per day, and children over 1.5 years old are prescribed a dose corresponding to 100 thousand units. In case of errors in the diet, Mezim can be used for several days, and if replacement therapy is necessary, the duration of treatment can be up to several months or years.

Side effects

The use of Mezim may lead to undesirable effects such as allergic reactions, discomfort in the epigastric region, nausea, constipation or diarrhea.

In case of long-term use of the drug, hyperuricosuria (increased levels of uric acid in the urine) may develop.

Additional information

A dark and dry place where the air temperature does not rise above 25 0 C is suitable for storing Mezim.

If stored correctly, the drug will remain usable for three years.

As an active ingredient in the composition Mezim Forte included pancreatin (powder from pork pancreas) at a concentration of 93.33 - 107.69 mg/tab. Minimum enzyme activity of the drug:

• amylase - 4.2 thousand euros. pharm. units;
• lipase - 3.5 thousand euros. pharm. units;
• protease - 250 euros. pharm. units

Auxiliary components: MCC, sodium starch glycolate (type A), anhydrous colloidal silicon dioxide, hypromellose, talc, Mg stearate, additives E122 (azorubine varnish) and E171 (titanium dioxide), simethicone emulsion, macrogol 6000, polyacrylate dispersion.

Composition of tablets Mezim Forte 10000/Mezim 20000: powder from pork pancreas (concentration, respectively 125 mg/tab./220–293.34 mg/tab.) with minimal lipolytic activity - 10/20 thousand euros. pharm. units, minimal amylolytic activity - 7.5/12 thousand euros. pharm. units, minimum proteolytic activity 375/900 euros. pharm. units

Auxiliary components: lactose monohydrate, MCC, anhydrous colloidal silicon dioxide, Mg stearate, crospovidone, methacrylic acid and ethyl acrylate copolymer (1:1 ratio), additives E122 (azorubic varnish) and E171 (titanium dioxide), hypromellose, triethyl citrate, simethicone emulsion , talc, polyethylene glycol 6000, polysorbate 80, sodium carmellose, sodium hydroxide.

Release form

• Sheathed Mezim Forte tablets. The tablets are pink, flat, cylindrical in shape, with almost plane-parallel surfaces and a beveled edge. Available packaged in blister packs of 20 pieces, packaging No. 20 or No. 80.
• Pills Mezim Forte 10000 in a red shell. The tablets are pink, film-coated, have almost flat-parallel surfaces and a beveled edge. Available packaged in blister packs of 10 pieces, packaging No. 20 or No. 50.
• Pills Mezim 20000 in a red shell. The tablets are round, biconvex, white (possibly grayish-white) in color, with a smooth surface, there may be brown inclusions on the break, and have a specific odor. Available packaged in blister packs of 10 pieces, packaging No. 10, No. 20 or No. 50.

Pharmacological action

The action of the drug is aimed at replenishment of life span deficit .

Pharmacodynamics and pharmacokinetics

The basis of the multienzyme drug Mezim is pancreatin . Wikipedia states that the substance is a powder that is obtained from the pork pancreas (PG) by extraction.

The substance contains excretory enzymes of the pancreas (amylase, lipase, trypsin and chymotrypsin), which are necessary for the digestion of proteins, carbohydrates and fats.

Pancreatin is not absorbed, but is excreted with the contents of the intestine. Most of the dose taken is broken down and denatured in the digestive canal under the influence of bacteria and digestive juices.

The decisive factors for the effectiveness of the drug are lipolytic activity pancreatin , as well as the proportion of trypsin, while amylase activity is important only in patients cystic fibrosis .

The drugs Mezim and Mezim Forte have differences. The coating of Mezim Forte tablets is not enteric-soluble, which is why the lipolytic activity of the drug is inactivated even when the pH value of the gastric juice is below 4.

Mezim Forte 10000 and Mezim 20000 tablets are coated with a red coating that does not dissolve under the influence of gastric juice and thus protects pancreatic enzymes from inactivation.

Dissolution of the membrane and release of enzymes occurs only in a neutral or slightly alkaline environment of the small intestine.

Indications for use of Mezim

Indications for use of Mezima Forte:

The tablets are designed to improve digestion. Indications for their use are:

• associated with specified disorders;
• functional disorders accompanied by accelerated transit of intestinal contents.

What do Mezim Forte 10000 tablets help with?

The drug is prescribed for:

• diseases accompanied by digestive disorders due to insufficient secretion of essential enzymes from the pancreas;
• conditions after simultaneous removal of sections of the small intestine and stomach;
• functional disorders accompanied by accelerated transit of intestinal contents;
• simultaneous consumption of fatty, hard to digest, unusual foods;
  flatulence, intestinal disorders;
• preparation for ultrasound or x-ray diagnostic studies.

When is Mezim 20000 prescribed?

Mezim 20000 is effective for:

• insufficiency of exocrine function of the pancreas;
• chronic inflammatory-dystrophic diseases of the liver, intestines, gall bladder, stomach;
• conditions after irradiation or resection of the listed organs, if these conditions are accompanied by disturbances in the digestion of food, flatulence ;
• to eliminate the consequences of dietary errors and improve digestion in patients with normal pancreatic function;
• preparing patients for ultrasound or x-ray diagnostic examinations;
• functional gastrointestinal disorders ( infectious intestinal diseases , irritable bowel syndrome ).

Contraindications

Contraindications for the use of Mezim Forte:

• hypersensitivity to pancreatin obtained from pig livestock, food additive E122 (synthetic food coloring azorubine), auxiliary components of tablets;
• spicy ;
• cases of exacerbation chronic pancreatitis ;
• obstructive (occurs when a mechanical obstacle appears) intestinal obstruction .

For pancreatitis, occasional use of the drug is possible during the period of restorative dietary nutrition when the exacerbation subsides.

Side effects

Side effects of Mezim Forte appear as:

• immediate hypersensitivity reactions (sneezing, watery eyes, skin rashes, bronchospasm );
• disorders of the digestive system, including nausea, diarrhea, abdominal pain, changes in bowel habits.

The annotation for Mezim Forte 10000 and Mezim 20000 states that in patients cystic fibrosis when using high doses of the drug, narrowing in the ileocecal region and in the ascending colon is sometimes possible.

Also in patients cystic fibrosis the possibility of increased uric acid excretion in the urine cannot be ruled out, especially when taking high doses pancreatin . To avoid the formation of uric acid stones in such patients, its concentration in the urine should be kept under control.

Instructions for use

Instructions for use Mezim Forte

Both adults and children over three years of age are prescribed to take one or two tablets with meals, without chewing and with a sufficient volume (about 200 ml) of liquid.

When carrying out enzyme replacement therapy, take two to four tablets of the drug.

The duration of the course is set individually.

Instructions for use Mezim Forte 10000

The dose of the drug depends on the deficiency of pancreatic enzymes in the duodenum and is selected individually.

When carrying out enzyme replacement therapy, the recommended dose is two to four tablets. If necessary, it can be larger.

Increasing the dose to relieve symptoms (abdominal pain, steatorrhea ) must be carried out under the supervision of a physician.

The permissible upper limit of the daily dose of lipase is 15-20 thousand euros. pharm. units/kg

The question of the dosage of the drug and the duration of the course of treatment is decided by the doctor.

How to take Mezim 20000?

The drug is taken with meals with plenty of warm water (the tablets are swallowed whole, without chewing).

The dose is set individually depending on the severity of the disease.

Unless otherwise directed, adults should take one or two tablets. Increase the dose, focusing on the weakening of symptoms, and only under the supervision of a doctor.

It is contraindicated to exceed a dose exceeding 15-20 thousand euros. pharm. units lipase/kg.

Treatment can last from several days (for dietary errors or digestive disorders) to several years (if it is necessary to prescribe enzyme replacement therapy to the patient).

Instructions for use of Mezim Forte for children

Mezim Forte is prescribed to children in a standard dosage - one or two tablets during meals with plenty of warm water.

For children under twelve years of age, Mezim Forte 10,000 is prescribed in a dose necessary to normalize bowel movements, but not exceeding 1.5 thousand euros. pharm. units lipase/kg. For adolescents 12-18 years old, the permissible upper limit of the daily dose of lipase is 15-20 thousand euros. pharm. units/kg

Overdose

Symptoms of overdose are unknown and, based on its composition, unlikely. Most likely, an overdose of the drug may result in increased side effects.

It is reliably known that during treatment with high doses of other drugs nancreatine patients developed hyperuricosuria And hyperuricemia .

Treatment of overdose is symptomatic.

Interaction

During treatment pancreatin containing drugs may reduce absorption , which may require additional intake into the body.

When used simultaneously with Miglitol or A carbose the glucose-lowering effect of the latter may decrease.

Terms of sale

Over the counter.

Storage conditions

Tablets should be stored at a temperature not exceeding 25°C, out of reach of children.

Best before date

Three years.

Special instructions

There are no special instructions for the use of Mezim Forte.

Precautionary measures for Mezim Forte 10000 and Mezim 20000

Intestinal obstruction is a known complication in patients cystic fibrosis , therefore, if symptoms reminiscent of this condition appear, you should remember the possible intestinal strictures .

The drug contains active enzymes that can damage the oral mucosa, even to the point of ulceration, so the tablets must be swallowed whole without chewing.

Patients with congenital galactose aversion , lactase deficiency and or with disorders of glucose/galactose absorption taking the drug is contraindicated.

There is no need to limit activities related to driving a car or dangerous machinery.

Analogues of Mezim Forte

Level 4 ATX code matches:

Cheap analogues of Mezim

Can be used as a more affordable drug substitute Pancreatin (price from 20 rubles per package No. 20) or Penzital (price for package No. 20 - 56 rubles, for package No. 100 - 165 rubles).

Which is better: Festal or Mezim?

Active substances of the drug — pancreatin , hemicellulose and bile components. The medicine is available in the form of enteric tablets.

The protective shell reduces the aggressive effects of acid, and also helps ensure that the active substances enter and begin to act in the intestines, where the help of enzymes is needed.

However, there are also disadvantages - the pills, like Mezim tablets, are taken during lunch, that is, they enter the intestines with food, and not necessarily with the first portion. The coating with which Mezim tablets are coated begins to dissolve in the stomach, due to which food enters the intestines with enzymes.

In Festal, one of the components that enhances its effect is bile, which facilitates the digestion of fats. And this is basically very good, but this effect is strictly contraindicated in patients with cholelithiasis .

Mezim or Creon - which is better?

Creon has an active ingredient identical to Mezim, but in the preparation Creon it is contained in a much higher concentration.

However, this is not the main difference between the drugs. First of all, they are distinguished by the form of release. Creon is available in the form of capsules filled with minimicrospheres.

The unique dosage form of the drug ensures its higher effectiveness (including for severe digestive disorders) - the microcomponents of the capsules are mixed almost evenly in the stomach with food, due to which the medicine enters the intestines with each serving of food, and the food is digested much more evenly.

It has been proven that the use pancreatin in the form of capsules filled with microspheres is much more effective than the use of conventional tablets and mini-tablets: in a patient during treatment Creon Digestive function is restored more quickly and completely, and the duration of the relapse-free period increases.

The downside of the drug is its high content of active components - concentrated accumulations of enzymes can irritate the intestines. In addition, it is known that the supply of enzymes in large quantities from the outside can provoke a situation when the pancreas stops producing its own enzymes.

High doses pancreatin effective in the treatment of severe pathologies, however, when it comes to treating pregnant women or children, the low content of enzymes in Mezim is its advantage over its analogue.

Mezim for children

According to the instructions, the drug can be used for children from the age of three.

Mezim during pregnancy and lactation

Is it possible to drink Mezim Forte during pregnancy?

Officially, there are no contraindications to the use of Mezim during pregnancy, but women still doubt whether pregnant women can take these pills and whether it will harm the unborn child.

The manufacturer indicates that Mezim tablets contain enzymes identical to those produced in the human body. Lipase acts on fats, amylase breaks down carbohydrates, and proteases work on protein foods.

The auxiliary components of the drugs are also not harmful to humans and, in addition, pancreatin is not absorbed into the bloodstream, but is excreted from the body with feces.

Considering all of the above, gynecologists and therapists often recommend Mezim to eliminate digestive problems in pregnant women. In each case of prescribing a drug during pregnancy, the doctor bears full responsibility for his decision.

Therefore, you should take the medicine only if you completely trust your doctor.

Use of Mezim during breastfeeding

Use is possible according to doctor’s instructions, which are made taking into account the ratio of the expected therapeutic effect for the mother’s body and the potential risks for the infant.