one capsule contains: active substance: meldonium - 250 mg or 500 mg.
Excipients: magnesium stearate, potato starch, colloidal silicon dioxide.
The composition of the capsule shell: gelatin, glycerin, purified water, titanium dioxide, sodium lauryl sulfate.
Description
Capsules hard gelatin cylindrical shape with hemispherical ends of white color (for a dosage of 250 mg).
Capsules hard gelatin cylindrical shape with hemispherical ends of white color (for a dosage of 500 mg).
Pharmacotherapeutic group
Other drugs for the treatment of heart disease.
ATS code: C01EB22.
Indications for use
As part of combination therapy in the following cases:
Cardiovascular diseases - stable angina pectoris, chronic heart failure (NYHA I-III functional class), cardiomyopathy, functional disorders of the cardiovascular system; acute and chronic ischemic disorders of cerebral circulation; reduced performance, physical and psycho-emotional overload; the recovery period after cerebrovascular accidents, head injuries and encephalitis.
Dosage and administration
For internal use. Due to the possible tonic effect, it is recommended to use the drug in the morning.
Adults appoint 0.5- (2-4 capsules of 250 mg or 1-2 capsules of 500 mg) per day, using the entire dose at once or dividing it into 2 times. The maximum daily dose is.
The duration of the course of treatment is 4-6 weeks. Treatment courses can be repeated 2-3 times a year.
Precautionary measures
For patients with liver and/or kidney failure
it is necessary to reduce the dose of meldonium.
Elderly patients with insufficiency of the liver and / or kidneys the dose of meldonium must be reduced.
Children under the age of 18 meldonium is not used due to the lack of data on safety and efficacy.
Many years of experience in the treatment of acute myocardial infarction and unstable angina in cardiology departments shows that meldonium is not a first-line drug for acute coronary syndrome.
Use during pregnancy or lactation
The safety of the drug during pregnancy has not been proven. To avoid possible adverse effects on the fetus, it is not prescribed during pregnancy.
In connection with the release of meldonium into mother's milk, in cases where the drug is used during lactation, breastfeeding should be discontinued.
Interaction with other drugs
The drug Meldonium-MIC can be used (together with long-acting nitrates and other antianginal agents, cardiac glycosides and diuretic drugs. It can also be combined with anticoagulants, antiplatelet agents, antiarrhythmic drugs and other drugs that improve microcirculation.
It should be borne in mind that Meldonium-MIC can enhance the effect of drugs containing glyceryl trinitrates, nifedipine, beta-blockers, other antihypertensive drugs and peripheral vasodilators.
Do not use together with other drugs containing meldonium, as the risk of side effects may increase.
Side effect
The drug is usually well tolerated. However, in sensitive patients, as well as in cases of overdose, side effects are possible.
The following side effects are classified according to the organ system groups and the frequency of occurrence of MedDRA: very often (> 1/10), often (> 1/100, 1/1000, 1/10 000 to
Blood and lymphatic system disorders
Not known: eosinophilia.
Immune System Disorders
Often: allergic reactions.
Cardiac disorders:
In some cases: tachycardia.
Circulatory system disorders
In some cases: low blood pressure.
Gastrointestinal disorders
Often: dyspepsia.
Nervous System Disorders
Often: headaches.
Not known: arousal.
Respiratory disorders, diseases of the chest and mediastinum
Not known: dyspnea.
General violations
Not known: general weakness.
Overdose
No cases of overdose have been reported. The drug is low toxic and does not cause severe side effects.
Symptoms: in case of low blood pressure, headaches, dizziness, tachycardia, general weakness are possible.
Treatment: symptomatic.
In case of severe overdose, it is necessary to monitor the functions of the liver and kidneys. Hemodialysis is not essential in case of an overdose of meldonium due to its pronounced protein binding.
Contraindications
hypersensitivity to meldonium or to any other component of the drug; increased intracranial pressure (in violation of venous outflow, intracranial tumors); hepatic or renal insufficiency (there is no sufficient data on the safety of use); During pregnancy and breastfeeding; children under 18 years of age (safety not tested).
Influence on the ability to drive vehicles and managemechanisms
An antiarrhythmic agent of the IB class, which improves metabolism - metabolic processes in the human body, is Meldonium. Instructions for use suggest taking capsules or tablets of 250 mg and 500 mg, injections in ampoules for injections for the treatment of cerebrovascular disorders, recuperation in athletes, coronary artery disease.
Important! Meldonium is recognized as doping. Its use in professional sports is prohibited!
Composition and form of release
Meldonium comes to pharmacies in the form of:
- capsules 500 mg and 250 mg;
- solution for injections (injections).
The active substance is meldonium dihydrate. Its volume in tablets or capsules is 250 mg or 500 mg. 1 ml of solution contains 100 mg.
Pharmacological properties
Means that improves metabolism, an analogue of gamma-butyrobetaine. Suppresses gamma-butyrobetaine hydroxynase, inhibits the synthesis of carnitine and the transport of long-chain fatty acids through cell membranes, prevents the accumulation in cells of activated forms of unoxidized fatty acids - derivatives of acylcarnitine and acylcoenzyme A.
Under conditions of ischemia, it restores the balance of the processes of oxygen delivery and its consumption in cells, prevents the violation of ATP transport; at the same time, it activates glycolysis, which proceeds without additional oxygen consumption.
As a result of a decrease in the concentration of carnitine, gamma-butyrobetaine, which has vasodilating properties, is intensively synthesized. The mechanism of action determines the diversity of its pharmacological effects: increased efficiency, reduced symptoms of mental and physical overstrain, activation of tissue and humoral immunity, cardioprotective effect.
Efficiency
In the case of acute ischemic myocardial damage, it slows down the formation of a necrotic zone, shortens the rehabilitation period. In heart failure, it increases myocardial contractility, increases exercise tolerance, and reduces the frequency of angina attacks.
In acute and chronic ischemic disorders of cerebral circulation, it improves blood circulation in the focus of ischemia, promotes the redistribution of blood in favor of the ischemic area. Effective in vascular and dystrophic pathology of the fundus.
It has a tonic effect on the central nervous system, eliminates functional disorders of the nervous system in patients with chronic alcoholism with withdrawal syndrome.
What is Meldonium for?
Indications for use include complex therapy:
- physical overvoltage;
- withdrawal syndrome in chronic alcoholism;
- reduced performance;
- disorders of cerebral circulation;
- dishormonal cardiomyopathy;
- postoperative rehabilitation.
What helps parabulbar introduction:
- retinal vein thrombosis;
- retinopathy (diabetic and hypertensive);
- retinal hemorrhage;
- violation of blood circulation in the retina.
Instructions for use
When taken orally, a single dose is 0.25-1 g, the frequency of administration and the duration of treatment depend on the indications.
Parabulbarno enter 0.5 ml of injection with a concentration of 500 mg / 5 ml for 10 days.
With intravenous administration, the dose is 0.5-1 g 1 time per day, the duration of treatment depends on the indications.
Athletes are prescribed for rehabilitation therapy according to special schemes in combination with other means. Officially recognized as doping.
How to take in diseases?
- In case of impaired cerebral circulation, Meldonium is recommended during the period of exacerbation, 0.5 g once a day for 10 days, then in encapsulated form, 0.5 g daily for 14–21 days.
- In the chronic form of cerebral circulatory disorders, a course of treatment lasting 14–21 days is prescribed. The solution for injection is administered intramuscularly at 0.5 g 1 time per day or administered orally at 0.25 g (the frequency of administration depends on the severity of the patient's condition).
- Withdrawal syndrome requires a course of Meldonium therapy for 7-10 days. Then the patient is shown a four-time intake of the drug during the day, 0.5 g orally or twice - intravenously.
- With stable angina pectoris, the first 3-4 days are prescribed 0.25 g 3 times. Then it is taken orally twice a week at a daily dosage of 0.25 g 3 times. The duration of therapy is from 4 to 6 weeks.
- In case of cardialgia associated with dyshormonal myocardial dystrophy, the drug is administered intravenously by jet method 1 time per day, 0.5-1 g or intramuscularly up to 2 times a day, 0.5 g each. After 10-14 days, the encapsulated form is prescribed 0.25 mg in the morning and evening, treatment is continued for another 12 days.
- With an unstable form of angina pectoris and myocardial infarction, Meldonium is used intravenously by a jet method of 0.5 g or 1 g once a day. In the future, it is prescribed orally: 3-4 days - 0.25 g 2 times, then 2 days a week, 0.25 g 3 times a day.
- In case of vascular diseases of the fundus, retinal dystrophy, Meldonium is prescribed retrobulbar and subconjunctival in a dose of 0.05 g for 10 days.
- In chronic heart failure, the drug is administered intravenously in a jet method once a day at a dose of 0.5-1 g or replaced by an intramuscular injection of 0.5 g up to 2 times a day. After 10–14 days of treatment, the patient is transferred to 0.5 g capsules, which he takes 1 time in the morning. The course of treatment is from 4 to 6 weeks.
Contraindications
Side effects
- skin itching;
- redness;
- rash;
- edema;
- tachycardia;
- changes in blood pressure (arterial hypotension);
- psychomotor agitation;
- dyspeptic symptoms.
Children, pregnancy and lactation
Meldonium is not prescribed to pregnant women, since it has not been possible to prove its safety to mother and child. If you need to prescribe a medicine to a nursing woman, then breastfeeding is stopped for the duration of therapy: it is not known whether the substance penetrates into milk.
In children and adolescents under the age of 18, the efficacy and safety of meldonium has not been established. Meldonium in the form of capsules is contraindicated for use in children and adolescents under the age of 18; in the form of syrup - in children under the age of 12 years.
special instructions
Use with caution in diseases of the liver and / or kidneys, especially for a long time.
Many years of experience in the treatment of acute myocardial infarction and unstable angina in cardiology departments shows that meldonium is not a first-line drug in acute coronary syndrome.
Interaction
With simultaneous use with Nitroglycerin, alpha-blockers, Nifedipine, peripheral vasodilators, there is a possibility of tachycardia and arterial hypotension. Enhances the action of antihypertensive, antianginal drugs, cardiac glycosides.
Perhaps a combination with antianginal drugs, anticoagulants, antiarrhythmic drugs and diuretics.
Important! Do not use simultaneously with other preparations containing meldonium.
Meldonium's analogs
According to the structure, analogues are determined:
- Vasomag.
- Meldonium dihydrate.
- Idrinol.
- Meldonium Organica (Binergia, Escom).
- Angiocardil.
- 3-(2,2,2-Trimethylhydrazinium) propionate dihydrate.
- Cardionate.
- Midolat.
- Meditern.
- Melfor.
For the treatment of physical and mental overload, recovery of the body, analogues are prescribed for the action:
Holiday conditions and price
The average price of Meldonium (injections 5 ml No. 10) in Moscow is 145 rubles. In Ukraine, you can buy medicine for 195 hryvnia. in Kazakhstan, pharmacies offer an analogue of Mildronate. In Minsk, the drug is sold for 4-6 bel. rubles. You will need a prescription to get the medication.
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The drug Meldonium is now well known - after the doping scandal, those who are not interested in pharmaceuticals and have no heart problems learned about it. The practice of using the drug by athletes raised the question of whether the drug can be taken by healthy people to increase efficiency and endurance. You will not find Meldonium tablets on sale, as this is a non-existent form of the drug. When taken orally, capsules are used.
The drug is available in the form of capsules for oral administration and solution for injection. The active ingredient in the composition is meldonium dihydrate.
International non-proprietary name
Meldonium, Meldonium
ATX
C01EB Other medicines for treating heart problems.
pharmachologic effect
Meldonium affects the metabolism in cells, normalizes metabolism in conditions of lack of oxygen or reduced blood supply. Supports the mechanism of metabolic processes in the heart. Reception Meldonium affects the level of sugar in the blood, lowers it. With ischemia, it improves blood circulation in the affected area, slows down the processes of necrosis.
The use of the tool increases efficiency, makes a person more resilient. Meldonium improves cerebral circulation, facilitates the processes of oxygen uptake by the body, and has a cardioprotective and adaptogenic effect.
Pharmacokinetics
When taken orally, the highest concentration of the active substance is fixed after 1-2 hours, when injected - immediately after the injection.
The process of excretion from the body occurs after 3-6 hours.
What is Meldonium for?
The drug in most cases is prescribed for disorders of the cardiovascular system and pathologies of the blood circulation of the brain. It is used in the treatment of chronic ischemic disorders, heart failure, damage to the heart muscle due to hormonal imbalance, pathologies of the retina.
In addition to vascular diseases, Meldonium is taken during asthenic conditions, in situations requiring increased physical or mental stress. It is widely used among professional athletes during training. Sometimes doctors prescribe in the complex therapy of various disorders, such as influenza, cervical osteochondrosis, rickets.
It is used as part of the complex treatment of withdrawal symptoms in alcoholism.
Contraindications
The medicine can not be used for:
- the presence of an increased reaction to the active substance;
- high levels of intracranial pressure;
- pregnancy and lactation (no studies have been conducted on the safety of the drug);
- under 18 years of age.
Patients with impaired renal function and liver disease should use the drug with caution, consult a doctor and be under his control during treatment.
How to take Meldonium
Depending on the form of the drug, Meldonium is taken orally, administered intravenously, intramuscularly or parabulbarno (for ophthalmic disorders).
Dosage, duration of the course of use and frequency of administration depends on the indications for use. It is determined together with the doctor.
In most cases, a single dose is 2 capsules of 250 mg, taken twice a day.
Before meals or after
Dosage for diabetes
In the treatment of diabetes, Meldonium is used in a course. The dosage and duration of therapy is prescribed by the doctor.
Meldonium side effects
Undesirable effects while taking Meldonium can be manifested by allergic reactions, digestive problems, heart palpitations, general agitation, changes in blood pressure (often lowering).
Influence on the ability to control mechanisms
The use of Meldonium does not affect the ability to concentrate and does not slow down psychomotor reactions, so there are no restrictions on driving a car during the period of therapy.
special instructions
Medical practice shows that in the treatment of patients with acute myocardial infarction and unstable angina, this medicine does not belong to the essentials.
The World Anti-Doping Agency has included the drug in the list of substances that are prohibited for use.
Use in the elderly
Elderly patients use the drug according to the instructions, provided they have no contraindications.
Assignment to children
Use during pregnancy and lactation
There is no clinical evidence that the drug does not have a pathological effect on the fetus and does not penetrate into breast milk, so its use is not recommended.
Overdose
When using an excessive amount of the drug, pressure may decrease, dizziness and headache may appear, tachycardia and weakness are sometimes observed. Treatment is aimed at eliminating the symptoms of an overdose.
Interaction with other drugs
Meldonium increases the effect of drugs that lower blood pressure, alpha-blockers, cardiac glycosides.
Alcohol compatibility
Meldonium does not interact with ethanol, but concomitant use with drinks containing alcohol is not recommended due to possible stress on the cardiovascular system.
The drug is used in the treatment of alcohol withdrawal syndrome.
Analogues
Analogues of Meldonium - Mildronat, Idrinol, Kardionat.
Conditions for dispensing from a pharmacy
The instructions for use indicate that the drug is sold by prescription.
Can I buy without a prescription
In pharmacies, the drug Meldonium is dispensed upon presentation of a prescription by the buyer.
Price
Prices for Meldonium start at 100 rubles.
Storage conditions of the drug
In order to avoid spoilage of the medicine, it is worth storing it at a temperature not exceeding 25 ° C. Do not create conditions under which the drug can be found by children.
The mechanism of action of the drug
Meldonium: True Energetic
Mildronate Meldonium instructions for use
Mildronate Meldonium instruction
Meldonium is a Russian-made hormonal drug that relieves pain and improves blood circulation in the brain, and was first synthesized in the Latvian USSR by a group led by Ivars Kalvins.
The drug was obtained as a result the complex process of synthesizing the dihydrate (ester) and passing it through a column with ion-exchange resins.
In contact with
Description of the medicinal product
In its pure form, it is a hygroscopic powder, easily soluble in water. Meldonium is difficult to dissolve in alcohol. It is produced in the form of aqueous solutions for injection, the main active substance of which is meldonium dihydrate.
Also under the name "Mildronate" is produced in Latvia in the form of tablets (capsules).
The most effective meldonium with hypoxia (chronic lack of oxygen in the tissues of the body and lungs), ischemia. It is an excellent pacemaker.
Unfortunately, professional athletes - as well as amateur athletes before competitions - cannot take meldonium, since the drug is considered hormonal and, according to American doctors, a prohibited stimulant (doping).
However, scientific studies have not yet confirmed the data that the drug directly affects the endurance of the body.
The creator of the drug still does not understand why meldonium is considered doping. Here is his response (abridged) to the "doping scandal" with meldonium:
The drug was patented and approved for use in the United States in 1984. Since then, there have been no complaints. An increase in endurance was observed only in older people suffering from angina pectoris.
Professor Ivars Kalvins.
So what is meldonium - a doping and metabolite dangerous to health, or a panacea for coronary heart disease and a "vitamin" for the brain? Let's try to figure it out together, having studied the instructions for using the drug, its side effects and contraindications.
Meldonium Upgrade t vital activity of the brain, prolongs the life of elderly patients with angina pectoris. For young people, this drug is prescribed in case of pathological ischemia, with hemorrhage of the eye vessels (the so-called "retinal" hemorrhage), with diseases of the cerebral vessels. The action of meldonium on the body is achieved due to the direct inclusion of the active substance in the main metabolic functions of the human body.
Due to the same property of the active substance, meldonium is used both in cardiology (prevention of heart attacks, stimulation of the myocardium, strengthening of the heart muscles) and in ophthalmology (elimination of retinal hemorrhages, improvement of the supply of oxygen to the eye vessels).
Meldonium is absorbed from the gastrointestinal tract, is transformed in the body into metabolites, which are broken down and subsequently excreted by the kidneys. In the case of injections of aqueous solutions, the effect occurs within two hours after taking the drug.
Indications for use
Usually the drug is used together with other drugs in complex therapy. With a special effect, this medicine is used for:
- Circulatory disorders of the brain (prevention of strokes).
- Reduced efficiency and a feeling of general fatigue due to lack of oxygen in the body.
- Poisoning of the brain and a decrease in cardiac activity in chronic alcoholism.
- Functional and structural changes in the heart muscle in the absence of pathologies of the coronary vessels (infarction prevention).
- Vascular anemia and other ischemic diseases.
Meldonium is especially effective during postoperative therapy, its pharmacological properties make the drug indispensable for recovery after acute cardiovascular diseases.
Price and release form
Ampoules with an aqueous solution of the drug, produced by the Russian concern Eskom NPK, are the cheapest. Approximately 113-123 rubles for 10 ampoules of 5 milliliters.
"Meldonium Organica" from another Russian manufacturer is more expensive: from 183 to 210 rubles for the same ten five-ml ampoules.
The Latvian analogue of meldonium ("Mildronate") is a capsule with the same active substance and is sold in pharmacies without a prescription, but at a higher price, from 310 to 350 rubles per package with 40 ampoules of 250 milligrams.
Analogues of the drug and reviews
The closest analogues of the drug meldonium are injectable solutions of the same active substance produced in Russia:
- Vazomag (Russia). This drug, judging by the reviews on the Internet, is most effective for treating fatigue syndrome, for increasing the activity of the brain (due to the saturation of blood vessels with oxygen).
- (Russia). This medicine is optimal for the treatment of coronary heart disease and costs about 350 rubles for ten 3 ml ampoules.
Meldonium analogues are also available in capsules or tablets. This form of release relieves patients of all the difficulties associated with injections. One tablet of the drug may contain from 250 to 50 milligrams of the drug. The best of these analogues in terms of price to pharmacological speed and efficiency in domestic pharmacies are considered:
There are practically no reviews on the Internet about the last two drugs, and they are rare in pharmacies, however, on Internet portals dedicated to the drug, they are confidently called among the analogues of meldonium. But the first two brands have an impressive list of positive reviews. For example, Maria Pavlovna Vitushinskaya from Vorkuta writes:
Or here is another symptomatic response:
You can get even more reviews (and very different ones!) About the drug on the Internet forums dedicated to this drug, for example, such as "SMT Mildronate" or "Bodybuilding Forum: Meldonium".
Indications for use and contraindications for meldonium analogues of the drug are basically the same as for the drug itself, since the active substance (meldonium dihydrate) is the same in them. Somewhere it is less, substances that improve absorption are added in the capsules of cardionate and mildronate.
However, the original drug in ampoules remains the most effective for
Contraindications
According to all instructions, the drug is categorically contraindicated only when increased intracranial pressure. First, take a course of treatment for high blood pressure in the vessels of the brain (most often, this is a course with diuretic and antihypertensive drugs).
With great care, this medicine should be used during pregnancy and breastfeeding.
Attention! Meldonium has a number of side effects, its use should be discontinued in cases of detection:
- tachycardia,
- Excessive excitement.
- Skin itching.
Only with the consent of the attending physician should meldonium be used in combination with other substances that stimulate blood circulation in the vessels or the heart muscle (such as or cinnarizine).
And also, if you have been using the drug for a long time, you should monitor the condition of the kidneys and liver, take drugs that support their work (for the liver ─ karsil, for example, and for the kidneys - lingonberry tea).
No other particularly terrible contraindications of meldonium have been found by science.
P N016028/02-200509Trade name of the drug
Mildronate ® .International non-proprietary name
meldonium.chemical name
3-(2,2,2-trimethylhydrazinium)propionate dihydrate.
Dosage form
solution for intramuscular, intravenous and parabulbar administration.Compound
1 ml of solution contains:active substance- meldonium dihydrate 100 mg;
excipient- water for injections.
Description
Transparent colorless liquid.
Pharmacotherapeutic group
metabolic agent.ATC code: C01EB.
Pharmacological properties
PharmacodynamicsMeldonium (Mildronate ®) is a structural analogue of gamma-butyrobetaine, a substance found in every cell of the human body.
Under conditions of increased load, Mildronate ® restores the balance between the delivery and demand of cells for oxygen, eliminates the accumulation of toxic metabolic products in cells, protecting them from damage; also has a tonic effect. As a result of its use, the body acquires the ability to withstand the load and quickly restore energy reserves. Due to these properties, Mildronate ® is used to treat various disorders of the cardiovascular system, blood supply to the brain, as well as to increase physical and mental performance. As a result of a decrease in the concentration of carnitine, gamma-butyrobetaine, which has vasodilating properties, is intensively synthesized. In case of acute ischemic damage to the myocardium, Mildronate ® slows down the formation of the necrotic zone and shortens the rehabilitation period. In heart failure, it increases myocardial contractility, increases exercise tolerance, and reduces the frequency of angina attacks. In acute and chronic ischemic disorders of cerebral circulation, Mildronate ® improves blood circulation in the focus of ischemia, promotes the redistribution of blood in favor of the ischemic area.
The drug eliminates functional disorders of the nervous system in patients with chronic alcoholism with withdrawal syndrome.
Pharmacokinetics
The bioavailability of the drug after intravenous administration is 100%. The maximum plasma concentration is reached immediately after its administration. It is metabolized in the body with the formation of two main metabolites, which are excreted by the kidneys. The half-life (T 1/2) is 3-6 hours.
Indications for use
In the complex therapy of coronary heart disease (angina pectoris, myocardial infarction); chronic heart failure and dyshormonal cardiomyopathy, as well as in the complex therapy of acute and chronic disorders of the blood supply to the brain (stroke and cerebrovascular insufficiency). Hemophthalmos and retinal hemorrhages of various etiologies, thrombosis of the central retinal vein and its branches, retinopathy of various etiologies (diabetic, hypertensive).Reduced performance; mental and physical overload (including athletes).
Withdrawal syndrome in chronic alcoholism (in combination with specific alcoholism therapy).
Contraindications
Hypersensitivity to the components of the drug, increased intracranial pressure (in case of impaired venous outflow, intracranial tumors), age up to 18 years (efficacy and safety have not been established), pregnancy, lactation.Carefully
With diseases of the liver and / or kidneys.
Use during pregnancy and during breastfeeding
The safety of use in pregnant women has not been studied, therefore, in order to avoid possible adverse effects on the fetus, its use is contraindicated. The excretion of the drug Mildronate ® with milk and its effect on the health of the newborn have not been studied, therefore, if necessary, breastfeeding should be stopped.Dosage and administration
In view of the possible development of an exciting effect, it is recommended to apply in the morning. Mildronate is prescribed intramuscularly (in / m), intravenously (in / in) and parabulbarno.The route of administration, doses and duration of the course of treatment are set individually, depending on the indications, the severity of the condition, etc.
1. Cardiovascular disease
As part of complex therapy:
The general course of treatment is 4-6 weeks.
2. Violation of cerebral circulation
As part of complex therapy in the acute phase, 0.5 g (5 ml of Mildronate ®) 1 time per day i.v. for 10 days, switching to oral administration of 0.5-1 g. weeks. In chronic cerebrovascular insufficiency (dyscirculatory encephalopathy), 0.5 g (5 ml of Mildronate ®) intramuscularly or intravenously 1 time per day for 10 days, then 0.5 g orally. The general course of treatment is 4-6 weeks.
Repeated courses (usually 2-3 times a year) are possible after consultation with a doctor.
3. Ophthalmopathology (hemophthalmos and retinal hemorrhages of various etiologies, thrombosis of the central retinal vein and its branches, retinopathy of various etiologies (diabetic, hypertensive)).
0.05 g (0.5 ml of Mildronate®) parabulbarno for 10 days. Including used as part of combination therapy.
4. Mental and physical overload
0.5 g (5 ml of Mildronate®) intramuscularly or intravenously 1 time per day. The course of treatment is 10-14 days. If necessary, the treatment is repeated after 2-3 weeks.
5. Chronic alcoholism
0.5 g (5 ml of Mildronate ®) intramuscularly or intravenously 2 times a day. The course of treatment is 7-10 days.
Side effect
Rarely - allergic reactions (redness, rashes, itching, swelling), as well as dyspepsia, tachycardia, a decrease or increase in blood pressure, agitation. Very rarely - eosinophilia, general weakness.Overdose
Symptoms: decrease in blood pressure, accompanied by headache, tachycardia, dizziness and general weakness.Treatment: symptomatic.
Mildronate ® is low toxic and does not cause side effects dangerous to the health of patients. Interaction with other drugs
Can be combined with antianginal agents, anticoagulants, antiplatelet agents, antiarrhythmic agents, diuretics, bronchodilators. Enhances the action of cardiac glycosides.
In view of the possible development of moderate tachycardia and arterial hypotension, caution should be exercised when combined with nitroglycerin, nifedipine, alpha-blockers, other antihypertensive drugs and peripheral vasodilators, since Mildronate ® enhances their effect.
special instructions
Many years of experience in the treatment of acute myocardial infarction and unstable angina in cardiology departments shows that Mildronate is not a first-line drug for acute coronary syndrome and its use is not urgently needed. Influence on the ability to drive vehicles and mechanismsThere are no data on the adverse effect of the drug Mildronate ® on the speed of the psychomotor reaction.
Release form
Solution for intramuscular, intravenous and parabulbar administration, 100 mg/ml.5 ml in a colorless glass ampoule with a line or a break point.
5 ampoules in a blister pack made of PVC film or uncoated polyethylene terephthalate film (pallet).
Two cellular packages (pallets) together with instructions for use in a pack of cardboard.
Storage conditions
Store at a temperature not exceeding 25 °C.Do not freeze!
Keep out of the reach of children.
Shelf life
4 years.Do not use after the expiry date stated on the packaging.
Terms of dispensing from pharmacies
On prescription. Registration certificate holderJSC "Grindeks" St. Krustpils, 53, Riga, LV-1057, Latvia.
Manufacturer(s)
-JSC "Sanitas" st. Veiveryu 134 V, Kaunas, LT-46352, Lithuania-Elfa Pharmaceutical Company S.A. st. Wincentego Pola, 21, Jelenia Gora, 58-500, Poland
-PJSC "Pharmstandard-UfaVITA", Russia. 450077, Republic of Bashkortostan, Ufa, st. Khudaiberdina, 28;
-HBC Pharma s.r.o. st. Sklabinska 30, Martin, 036 80, Slovakia Organizations accepting claims
- Representative office in Moscow (in the production of the drug Sanitas JSC, Lithuania; Elfa Pharmaceutical Company S.A., Poland; HBM Pharma sr.o., Slovakia).
117556, Moscow, Varshavskoye shosse, 74, bldg. 3, 5th floor,
- PJSC "Pharmstandard-UfaVITA", Russia (in the production of the drug PJSC "Pharmstandard-UfaVITA", Russia). 450077, Republic of Bashkortostan, Ufa, st. Khudaiberdina, 28.
